Only about 750 cases have been reported in scientific literature. Adenomatoid odontogenic tumor aot, a benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly females in the. Adenomatoid odontogenic tumor aot, a benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly females in the second decade. Adenomatoid odontogenic tumor constitutes an uncommon benign odontogenic tumor which is wellknown as twothirds tumor twothirds of adenomatoid tumors occur in the maxilla, twothirds occur in young females, twothirds of the cases are associated with unerupted teeth and twothirds of the affected teeth are canines. Adenomatoid odontogenic tumor aot is a distinct odontogenic tumor that is exclusively odontogenic epithelium in origin which accounts for about 37% of all odontogenic tumors. Adenomatoid odontogenic tumour aot is a benign noninvasive odontogenic tumour, having mostly a slow and sustained growth pattern.
Adenomatoid odontogenic tumor aot is a wellrecognised slow growing benign tumor derived from complex system of dental lamina or its remnants. Expression of ck14 and vimentin in adenomatoid odontogenic tumor and dentigerous cyst. This epithelial tumor has an inductive effect on the odontogenic ectomesenchyme with dentinoid frequently being produced. This lesion is categorised into three variants of which the more common variant is follicular type which is often mistaken for dentigerous cyst. Two thirds of cases are located in the anterior maxilla, and one third are present in the anterior mandible. Pdf adenomatoid odontogenic tumor, an uncommon tumor. The histologic presentation, histogenesis, and suggested treatment are discussed. Although they do not normally contain odontogenic tissue, they are probably odontogenic because of their site of origin. Dentigerous cyst associated with adenomatoid odontogenic. It has two clinicopathologic variants, namely intraosseous follicular and. Introduction the adenomatoid odontogenic tumour aot is a benign, hamartomatous lesion of odontogenic epithelial origin1. Adenomatoid odontogenic tumor e16 introduction adenomatoid odontogenic tumor aot is an uncommon benign neoplasm of odontogenic epithelial origin accounting for less than 3% of all odontogenic tumors. Several new facets of this tumour appear from the approximately 250 cases having. Aggressive behavior and recurrence after enucleation is exceedingly rare thus supporting its questionable hamarmatous nature 3,4,6,9.
A well circumscribed lesion derived from odontogenic epithelium that usually occurs around the crowns of unerupted anterior teeth of young patients and consists of epithelium in swirls and ductal patterns interspersed with spherical calcifications. The adenomatoid odontogenic tumor is completely benign. Int j oral maxillofac surg decade of life, the first in a girl and the figure 1. Adenomatoid odontogenic tumor is a successional tooth. When grown, one can palpate a hard and large lesion. Oral manifestations related to ss mainly include dental defects, papillary lesions in the oral mucosa, giant cell lesions of the jaws, and odontogenic tumors. Adenomatoid odontogenic tumor aot is a benign lesion, rare, slow growing and progressive. Its occurrence represents 3% of all odontogenic tumors.
Several tumors exist, which only appear to occur in the jaws. Pdf here we report a case of adenomatoid odontogenic tumor aot in the maxilla in a young girl aged 14 years and its surgical management. A 35year retrospective study of 250 cases in an indian maharashtra teaching institute. Multiple adenomatoid odontogenic tumors in a patient with.
In the past, this tumor has been referred to as adenoameloblastoma or ameloblastic adenomatoid tumor. Adenomatoid odontogenictumourjawelinicalstatistics. Adenomatoid odontogenic tumor aot formerly called an adenoameloblastoma, a somewhat deceptive term that should be discarded, the aot represents about 37 % of all odontogenic tumors. This paper reported a case of aot, in a 16yearold female, associated with an impacted maxillary left lateral incisor. Odontogenic tumours an update diagnostic histopathology. In some cases these small calcifications combine to form large. Adenomatoid odontogenic tumor aot is an uncommon tumor of odontogenic origin. Adenomatoid odontogenic tumor aot is a relatively rare neoplasm. Hybrid odontogenic tumor, hybrid odontogenic cyst, hybrid odontogenic neoplasm, dentigerous cyst, calcifying odontogenic cyst, adenomatoid odontogenic cyst v w gruza a, choi j, chen c, et al. The adenomatoid odontogenic tumor aot is usually an asymptomatic slow growth lesion. Adenomatoid odontogenic tumour is a benign hamartomatous, noninvasive lesion with slow but progressive growth. Even though there is evidence that tumor cells originate from the epithelium of the tooths enamel, it has been suggested that. Treatment for large adenomatoid odontogenic tumors.
Adenomatoid odontogenic tumors represent 3 to 7% of all odontogenic tumors. Adenomatoid odontogenic tumor associated with an impacted. Ameloblastoma, adenomatoid odontogenic tumor, jaws, odontogenic tumors, odontoma how to cite this article. Adenomatoid odontogenic tumour aot adenomatoid odontogenic tumour aot consists of spindleshaped cells forming nodules that may contain droplets of eosinophilic material and columnar cells lining spaces that are either empty or contain eosinophilic material.
G12v mutations were reported in a small cohort of aot. The authors present two examples of a combined epithelial odontogenic tumor which contained areas diagnostic for both adenomatoid odontogenic tumor and calcifying epithelial odontogenic tumor. Benign tumors include benign epithelial odontogenic tumors, benign mixed epithelial and. Adenomatoid odontogenic tumor aot is a benign neoplasm of odontogenic epithelium.
Adenomatoid odontogenic tumour displacing multiple teeth. Odontogenic tumors are both benign and malignant and have been classified accordingly by who in 1992 which was further divided into sub divisions by white dk in 2004. Case report cystic adenomatoid odontogenic tumor sonalgrover, 1 ahmedmujibbangalorerahim, 2 nithinkavasseryparakkat, 3 shekharkapoor, 4 kumudmittal, 5 bhushansharma, 1 andanilbangaloreshivappa 6 department of oral pathology and microbiology, christian dental college, cmc, ludhiana, punjab, india. Pdf adenomatoid odontogenic tumours with a diameter of more than 4 cm are uncommon. Ahire ms, tupkari jv, chettiankandy tj, thakur a, agrawal rr. It affects young patients and is usually associated with an impacted tooth, generally the canine. Two thirds of the cases are associated with an impacted tooth usually being the canine. Ameloblastomas and adenomatoid odontogenic tumors aots are. Adenomatoid odontogenic tumor aot belongs to a group of rare benign odontogenic lesions and constitutes approximately 37% of all odontogenic tumors 7 8 9. Adenomatoid odontogenic tumor aot is a benign lesion from the dental lamina or its remains.
This is an open access article distributed under the terms of the creative commons attributionnoncommercialsharealike 3. Expression of ck14 and vimentin in adenomatoid odontogenic. It is well known for its unique histopathologic features, predilection for young individuals, and innocuous behavior. Adenomatoid odontogenic tumor pdf adenomatoid odontogenic tumor aot, a benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly. Here, we report the first case of multiple adenomatoid odontogenic tumor observed in a patient with ss. Benign and slowgrowing, it is believed to originate from the remnants of the dental lamina or the enamel organ 1,46. The female population has the highest incidence of reported cases, with a prevalent age range of 10 to 30 years, mainly the second decade of life. Odontogenic keratocysts make up around 19% of jaw cysts.
Overall, odontogenic tumors are rare and form only a small proportion of the lesions found in the jaw. Pdf background to present 14 cases of adenomatoid odontogenic tumor aot, highlighting. Adenomatoid odontogenic tumors are rare and differ from most other dentition related lesions in that they more frequently occur in the maxilla epidemiology. Adenomatoid odontogenic tumor is a hamartomous benign neoplasia of odontogenic origin. This paper reports a case of a 12yearold boy with a bony consistence tumefaction involving the area from teeth 12 to 17. In the whoiarc classification of head and neck pathology, this clinical entity had been known for years as the odontogenic keratocyst. Adenomatoid odontogenic tumor aot, a benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly. It is common for the tumor to cause shifting of neighboring teeth because tumor expansion is more common than teeth root resorption. Adenomatoid odontogenic tumor associated with dentigerous cyst of the maxillary antrum. Anna saito, akira taguchi, hiromasa hasegawa and hideaki kagami, a case of adenomatoid odontogenic tumor with unusual presentation extending from gingiva to periodontal space, journal of oral and maxillofacial surgery, medicine, and pathology, 10. Since its first description by ghosh in 1934, more than 160verifiable caseshave been reported worldwide115. It is a relatively uncommon neoplasm that accounts for about 3% of all odontogenic tumors being more common in the maxilla and in females, more often. Clinical statistics of the adenomatoid odontogenic tumour.
It is predominantly found in young and female patients, located more often in the. It is a benign hamartomatous, noninvasive lesion with slow but progressive growth. Adenomatoid odontogenic tumor is a benign epithelial odontogenic tumor. An unusual presentation of adenomatoid odontogenic tumor. Ameloblastoma and adenomatoid odontogenic tumor ncbi. The adenomatoid odontogenic tumor is an odontogenic tumor arising from the enamel organ or dental lamina. Adenomatoid odontogenic tumors pdf posted on january 29, 2020 by admin adenomatoid odontogenic tumor aot, a benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly. Adenomatoid odontogenic tumor case report case report vol. Full text pdf 2618k abstracts references50 citedby17 the present biological profile of the adenomatoid odontogenic tumour represents an updating of the data published by the authors from 1990 to 1996. The tumor which today is called adenomatoid odontogenic tumor aot was probably first described by dreibladt 1907, quoted in thoma 1970, who called the tumor pseudoadenoma adamantinum, and then by harbitz 1915, who called it adamantine cystadenoma gorlin and. Adenomatoid odontogenic tumors aot are exceptionally rare and benign, originating in the odontogenic epithelium and accounting for 2. The adenomatoid odontogenic tumour aot has been known by a number of descriptive names adenoameloblastoma, ameloblastic adenomatoid tumour, glandular ameloblastoma, and adenomatoid. Calcifying epithelial odontogenic tumors ceots and calcifying odontogenic cysts cocs are rare, benign odontogenic tumors.
We report two cases of an exceptional combination of these tumors with either an ameloblastic fibroodontoma or an odontoma. Aot is an uncommon lesion of odontogenic origin, which affects young individuals, with a female predilection and mostly occurring in the second decade. Enucleation of a rare hybrid odontogenic lesion in the. Pdf dentigerous cyst or adenomatoid odontogenic tumor. Peripheral adenomatoid odontogenic tumor in a cloak of an. This lesion is most commonly associated with an impacted maxillary canine. Notch signaling affects oral neoplasm cell differentiation. Benign odontogenic tumors are divided into three types based on the presence absense of odontogenic epithelium or ectomesenchyme. Adenomatoid odontogenic tumor aot is a slowgrowing. Adenomatoid odontogenic tumor aot is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst. They are also seen more frequently in females, most frequently in the second decade of life. Adenomatoid odontogenic tumor aot is an uncommon benign odontogenic lesion that affects young patients associated with an impacted tooth, usually canine.
698 1322 1545 1046 1114 1403 971 1519 1530 877 1051 1187 176 742 1500 1190 381 1274 228 1465 761 1385 915 1496 1072 328 107 343 985 539